Selective Impairment in Sympathetic Vasomotor Control With Norepinephrine Transporter Inhibition

Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibition.

BACKGROUND Norepinephrine transporter (NET) inhibition increases the responsiveness to vasoactive medications and attenuates the response to sympathetic stimuli. The phenomenon may be a result of impaired regulation of sympathetic vasomotor tone. METHODS AND RESULTS We studied the effects of the selective NET blocker reboxetine and placebo on baroreflex control of heart rate (HR) and sympathe...

Pulmonary vasomotor responses to epinephrine and norepinephrine in the cat. Influence of the sympathetic nervous system.

Altered sympathetic nervous reactivity and norepinephrine transporter expression in patients with postural tachycardia syndrome.

BACKGROUND Clinical observations in patients with postural tachycardia syndrome (POTS) suggest abnormal sympathetic nervous system activity and a dysfunction of the norepinephrine (NE) transporter (NET). METHODS AND RESULTS We examined sympathetic nervous system responses to head-up tilt by combining NE plasma kinetics measurements and muscle sympathetic nerve activity recordings and by quant...

Norepinephrine transporter inhibition alters the hemodynamic response to hypergravitation.

Sympathetically mediated tachycardia and vasoconstriction maintain blood pressure during hypergravitational stress, thereby preventing gravitation-induced loss of consciousness. Norepinephrine transporter (NET) inhibition prevents neurally mediated (pre)syncope during gravitational stress imposed by head-up tilt testing. Thus it seems reasonable that NET inhibition could increase tolerance to h...

Cholecystokinin selectively affects presympathetic vasomotor neurons and sympathetic vasomotor outflow.

Cholecystokinin (CCK) is a potential mediator of gastrointestinal vasodilatation during digestion. To determine whether CCK influences sympathetic vasomotor function, we examined the effect of systemic CCK administration on mean arterial blood pressure (MAP), heart rate (HR), lumbar sympathetic nerve discharge (LSND), splanchnic sympathetic nerve discharge (SSND), and the discharge of presympat...